• Anti-Cancer Effects Of Xao Tam Phan Paramignya Trimera Methanol Root Extract On Human Breast Cancer

    Xao tam phan (Paramignya trimera (Oliv.) Guillaum) is a Vietnamese traditionally medicinal plant found in treating numerous cancers. The preparation of Xao tam phan extracts including solvent type and extraction method have significant effects on extraction efficiency, phytochemical profile and biological activity. These studies aimed to analyze the end results of five various solvents (water, acetonitrile, methanol, ethyl acetate and hexane) and three different extraction methods (conventional, ultrasound-assisted and microwave-assisted) on phytochemical yield and antioxidant capacity of P. trimera root from Vietnam. The results indicate that methanol extracted the maximal yield of phytochemicals from P. trimera and exhibited the greatest antioxidant capacity, with eleven compounds were identified and quantified. Microwave-assisted extraction produced the maximal phytochemical yields (aside from total flavonoids) and antioxidant capacity, in comparison with conventional and ultrasound-assisted extractions. These data demonstrate that the use of methanol and microwave-assisted extraction are recommended for extraction of biologically active phytochemicals from P. trimera root for application in the nutraceutical and/or pharmaceutical industries.

    Drying methods, solvents and extraction methods greatly modify the phytochemical compounds and biological activity from plant materials. The aims with this study would determine the consequences of drying methods, various solvents and extraction methods on the phytochemical compounds and antioxidant capacity from Xao tam phan (Paramignya trimera) root obtained from Vietnam. The results demonstrated that microwave drying was an efficient method in eliminating water with regards to shortest drying time, lowest energy consumption as well as retention of phytochemical compounds and antioxidant capacity from the P. trimera root while methanol and microwave-assisted extraction were the very best solvent and means for greatest extraction from the phytochemical compounds and antioxidant capacity in the P. trimera root. The findings because of this study allow retaining the very best levels of phytochemical compounds and antioxidant capacity through the P. trimera root for potential application within the nutraceutical industry.
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